Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1446 | CA24292 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+DDI | 8 |
| 3 | 3TC+D4T+IDV | 22 |
| 4 | NFV+NVP+SQV | 35 |
| 5 | None | 24 |
| 6 | 3TC+AZT+IDV+RTV | 13 |
| 7 | 3TC+AZT+IDV+SQV | 32 |
| 8 | ABC+D4T+EFV+RTV+SQV | 104 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V75VA | K103N, V106M | K20R, V35M, E44D, K102KR, K122E, E169D, T200A, H208Y, R211K, K223Q, L228Q, I293V |
| >CA24292| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKIADFRELNKRTQDFWEVQLGIPHPAGLKRNKSMTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQQEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I, L33I, L89V | L10I, I13V, K20R, E35D, M36I, N37D, L63P, A71V, I93L | R57KN |
| >CA24293| codons 1-99 PQITLWQRPIVTVKIGGQLREALIDTGADDTVIEDIDLPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPTNVIGRNVLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |