Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9848 | CA24255 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 52 |
| 3 | D4T | 26 |
| 4 | 3TC+AZT | 47 |
| 5 | 3TC+AZT+SQV | 8 |
| 6 | 3TC+AZT+IDV | 104 |
| 7 | D4T+DDI+RTV+SQV | 21 |
| 8 | 3TC+ABC+AZT+NFV+NVP | 47 |
| 9 | 3TC+D4T+NFV+NVP | 39 |
| 10 | 3TC+D4T+EFV+NFV | 17 |
| 11 | APV+D4T+DDI+LPV | 55 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, I84V | L33F | L10I, R57K, D60E, I62V, L63P, A71V, I72T, I93L |
| >CA24255| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFVKVKQYE QVPIEICGHKVTGTVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, L210W, T215F | K219W | Y181C, G190A | V108I | V35M, T39A, K43E, K101Q, K104N, V118I, D123E, K166R, R172K, D177E, I202V, R211A, L228H, D237N, V245E, A272P, K277R, V292VI, E297K |
| >CA24254| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKNSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFKKQNPEIVI CQYMDDLYVASDLEIGQHRTKVEELRQHLWAWGFFTPDWKHQKEPPFHWMGYELHPNKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |