Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7075 | CA24141 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 34 |
| 2 | 3TC+ABC+AZT+NFV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | K14R, N37S, Q61E, L63P, A71AV, V77I, I93L |
| >CA24141| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD EIPIEICGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115YF, M184V | N348I | M16MV, Q207E, R211K, V245E, A272P, I293V, T338S, K390R, T403I, Q428R, L452S, K512R, S519N |
| >CA24140| codons 1-560 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWSYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEAWWIEYWQATWIPEWEFVNTP PLVKLWYRLEKEPIVGAETFYVDGAANRETKSGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |