Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1159 | CA24138 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 9 |
| 2 | DDI | 26 |
| 3 | D4T | 18 |
| 4 | AZT+D4T+IDV | 26 |
| 5 | AZT+DDI+NVP+RTV+SQV | 230 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K219E | Y181C | K20R, V35L, T69N, E79D, K102M, V179I, G196E, T200A, E203K, Q207E, D218DE, L228R, E248D, A272P, T286A, P294PS, E297K |
| >CA24138| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKLVDFRDLNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYMDDLYVGSDLEIEQHRAKIKELREHLLRWGFTTPEEKHQKEPPFRWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVISLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IV, V82T, I84V | T74P | L10Y, I15V, L19LI, K20M, K55N, D60E, L63P, H69R, K70T, L89M |
| >CA24139| codons 1-99 PQITLWQRPYVTIKVGGQIMEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFINVRQYE QIPIEICGRTAIGPVLVGPTPTNVIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |