Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3945 | CA24123 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | DDI | 21 |
| 3 | 3TC+D4T | 13 |
| 4 | 3TC+D4T+IDV | 8 |
| 5 | AZT+DDI+NFV | 91 |
| 6 | RTV+SQV | 30 |
| 7 | EFV+SQV | 21 |
| 8 | ABC+APV | 43 |
| 9 | None | 34 |
| 10 | 3TC+AZT+IDV+NFV+RTV | 30 |
| 11 | D4T+LPV+TDF | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F | K20R, E35D, M36I, N37E, R57K, I62V, L63P, A71V, I93L |
| >CA24123| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | Y188L | K43E, K101Q, V106I, V118I, K122KE, D123E, S162C, T200A, R211K, L228H, A272P, V292I, E297K |
| >CA24122| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |