Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4517 | CA24107 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 113 |
| 2 | AZT+DDC | 52 |
| 3 | 3TC+AZT | 54 |
| 4 | 3TC+D4T+NVP+RTV | 49 |
| 5 | 3TC+D4T+NVP+RTV+SQV | 65 |
| 6 | D4T+NVP+RTV+SQV | 108 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, V82A, I84V, L90M | L10I, I62V, L63H, A71V, V77I, I93L |
| >CA24107| codons 1-98 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFIKVRQYD QVHIEICGHKVIGTVLIGPTPANVIGRNLMTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215CY | F77L, K219HN | K101E, G190A | V108VI | V35I, E36ED, K43E, E44A, R83K, V118I, K122P, I178L, G196E, Q207E, A272P, K275R, K277R, K281KR, T286A, E297KR |
| >CA24106| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIDICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDLRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVASDLEIEQHRTKIEELREHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCRLLRGAKALTEVIPLTREAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |