Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4401 | CA24103 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT | 83 |
| 3 | D4T+DDI+NFV | 79 |
| 4 | 3TC+ABC+APV | 93 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, L90M | L33F, G73A | L10I, I13V, K14KR, L63P, V77I |
| >CA24103| codons 1-98 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFMKVRQYD QIPIEICGHKAIATVLIGPTPVNIIGRNLMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | P4S, T39S, K43E, E53D, V60I, V90I, K102Q, S162Y, G196E, A272P, K277R, A288S, K311R, D324E, M357T, R358K, G359S, K366R, A400T, E432D, D460N, V467I, K476Q, L491S, S519N, K558R | K527KHNQ |
| >CA24102| codons 1-560 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEEEGKISKIGPDNPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVIPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKSA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVISLTDTTNQQTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRRVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |