Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1534 | CA24069 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | AZT+DDC | 170 |
| 3 | AZT | 57 |
| 4 | 3TC+AZT | 17 |
| 5 | 3TC+AZT+IDV | 96 |
| 6 | DLV+NFV+SQV | 21 |
| 7 | D4T+DDI+RTV+SQV | 31 |
| 8 | D4T+DDI+IDV+NFV | 43 |
| 9 | APV+AZT+DDC+EFV+SQV | 40 |
| 10 | 3TC+APV+AZT+DDI+RTV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73C | L10I, D60E, I62V, L63P, I64V, K70R, V77I, I93L | I72DE |
| >CA24069| codons 1-98 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYE QVPVEICGHRAECTVLIGPTPVNIIGRNLMTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, L210W, T215Y | K103KN | A98AG | T39N, K43E, V118VI, K122P, D177E, V179I, I202IV, Q207QE, R211K, L228LR, Q278H, T286A, E291D, V292I, I293V |
| >CA24068| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRTKVEELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTDIVPLTEEA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |