Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4889 | CA24005 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 95 |
| 2 | AZT+DDI+DLV | 49 |
| 3 | 3TC+AZT+DLV | 116 |
| 4 | None | 37 |
| 5 | D4T+EFV+NFV | 68 |
| 6 | 3TC+AZT+DDI+NFV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36L, R41RK, K45KR, L63P, A71AT, V77I, I93L | I15IT, E35V |
| >CA24005| codons 13-99 IKTGGQLKEALLDTGADDTVLEVLNLPGKWKPRMIGGIGGFIKVRQYDQIPIEICGHKTI GTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | K11R, K32R, V35M, I50V, V60I, R83K, I135LV, K173Q, G196E, Q207QR, R211G, A272P, K277R, E297K |
| >CA24004| codons 1-303 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIRALMEICTEMEKEGKISKVGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRRHLLGWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |