Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1600 | CA23978 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 260 |
| 2 | AZT+DDI | 47 |
| 3 | None | 13 |
| 4 | 3TC+AZT+SQV | 21 |
| 5 | 3TC+D4T+IDV | 52 |
| 6 | RTV+SQV | 4 |
| 7 | 3TC+AZT+NVP | 34 |
| 8 | 3TC+AZT | 17 |
| 9 | ADV+D4T+EFV+RTV+SQV | 69 |
| 10 | D4T+DDI+NVP | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, M184V, L210W, T215Y | D67G, K219E | K101P, K103S | V108VI | V35M, T39A, E40F, K43E, V60I, S68G, R83RK, K104R, V118I, K122E, D177N, T200A, R211K, D218DE, L228H, T286A, E291D, E297K |
| >CA23978| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPI FAIKKKGGTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLPKSRSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVIPLTKEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, G48V, I54T, V82A | L33LF | L10I, L63P, I64L, A71V, I72V, I93IL |
| >CA23979| codons 1-98 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFTKVRQYD QIPLEICGHKVVGTVLVGPTPANIIGRNLLTQLGCTLN |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |