<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5126 CA23962 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 117
2 3TC+AZT+IDV 148
3 D4T+DDI+EFV 34
4 3TC+APV+AZT 94

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219E     E6EK, K20R, V35T, K43E, E44A, V60I, V118I, K122KE, P176Q, V179I, G196E, I202V, H208Y, R211K, I293V, E297P  
>CA23962| codons 1-300
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNQDIII
YQYVDDLYVGSDLEIEQHRTKVEELRQYLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTPEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, L90M L33F, G73S, L89V L10I, I13V, L24F, I62V, L63P, V77I, V82I, I93L  
>CA23963| codons 1-99
PQITLWQRPIVTVKIGGQLKEALFDTGADDTVFEEMNLPGRWKPKLIGGIGGFIKVRQYD
QVPIEICGHKAISTVLIGPTPINIIGRNVMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009