Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1137 | CA23914 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | None | 31 |
| 3 | DDC | 135 |
| 4 | D4T | 22 |
| 5 | D4T+DDI | 17 |
| 6 | 3TC+D4T+SQV | 26 |
| 7 | 3TC+AZT+IDV | 26 |
| 8 | 3TC+AZT | 22 |
| 9 | 3TC+AZT+RTV+SQV | 32 |
| 10 | 3TC+AZT | 81 |
| 11 | None | 7 |
| 12 | ABC+APV+EFV+RTV | 6 |
| 13 | ABC+APV+DLV+RTV | 3 |
| 14 | ABC+APV+DLV | 55 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115F, T215Y | K103N, Y181C | T39A, V90I, K122E, S162A, I202IV, A272P, K277R, Q278H |
| >CA23914| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGTKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V | Q58E | L10V, L63P, V82VI |
| >CA23915| codons 1-98 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKAIGTVVVGPTPINIIGRNLLTQIGCTLN |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |