<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
O607 659 South Africa 2009 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+EFV 26

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y A62V, V75T, K219E K103N, V106M   V35T, T39N, S48T, T69N, K104KR, K122E, D123N, I135M, K173T, D177E, I178M, T200A, Q207QK, R211K, V245Q  
>659| codons 1-262
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNELEKEGKITKIGPENPYNTPV
FVIKKKNSNRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKNRSMTVLDVGDAYFSVPL
DENFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELRKHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, R41K, L63P, H69K, V77I, L89M, I93L  
>659| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLIGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Posada Cespedes, S Learning evolutionary pathways of HIV-1 subtype C under lopinavir treatment IAS 2017, 2017
Van Zyl, GU Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens. PLoS ONE , 2013