Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1267 | CA23867 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | D4T+ 3TC | 23 |
| 3 | SQV+ D4T+ 3TC | 25 |
| 4 | SQV+ D4T+ ADV+ 3TC | 54 |
| 5 | D4T+ 3TC+ RTV+ SQV | 75 |
| 6 | ABC+ D4T+ DDI | 115 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I13V, K14R, L19I, L63P |
| >CA23867| codons 1-99 PQITLWQRPVVTVRIGGQIKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215FY | K219KQ | K20R, V35VL, T39TA, K43KN, V60I, K104N, V118VI, K122KE, I135T, I142IV, S162Y, I178IM, T200A, Q207E, A288AS, I293V |
| >CA23866| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELENEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRAKIEELREHLWRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |