Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2255 | CA23845 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ DDI | 28 |
| 2 | SQV+ DDI+ 3TC | 11 |
| 3 | DDI+ IDV+ 3TC | 51 |
| 4 | NVP+ IDV+ D4T | 73 |
| 5 | SQV+ NFV | 17 |
| 6 | DDI+ ABC+ 3TC+ AZT+ EFV | 121 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | K20I, I64V, T74S, V77I, I85V |
| >CA23845| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGSVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67N, Y115F, Q151M, M184I | V75I, F77L, F116Y, K219Q | Y181C, G190A | I31L, T58N, S68G, T69TI, V90I, K101Q, D123E, K166R, D177E, T200I, I202V, R211K, H221Y, V245T, D250E, A272P, K277R, I293V |
| >CA23844| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALVEICTELEKEGKISKIGPENPYNNPV FAIKRKNGIKWRKLIDLRELNKRTQDFWEIQLGIPHPAGLQKKKSVTVLDVGDAFYSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYIDDLYVASDLEIGQHRIKVEELRQHLLKWGFTTPDQKYQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |