Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1529 | CA23830 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 39 |
| 2 | D4T | 57 |
| 3 | 3TC+D4T | 30 |
| 4 | 3TC+D4T+IDV | 22 |
| 5 | 3TC+D4T+NFV | 35 |
| 6 | 3TC+D4T+NVP | 15 |
| 7 | D4T+DDI+RTV+SQV | 15 |
| 8 | D4T+DDI | 71 |
| 9 | ABC+D4T+NVP | 86 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69E_G, L210W, T215Y | A62AV | Y188L | A98AG | T39TA, E40X, K43KE, E44ED, V60I, S68SG, V75X, K101KQ, V106IL, V118I, D123E, I135V, S162C, G196E, T200A, E203DV, Q207DE, H208HY, R211RK, K238KR, T286A, I293V |
| >CA23830| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAXLEEDGKISKIGPENPYNTPI FVIKKKNGEKWRKLXDFRELNKRTQDFWEVQLGIPHPGGLQKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIEQHRAKIDELRDYLWKWGFYTPDKKHQKEPPFLWMGYELHPDRWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37S, R57K, L63P, A71T, V77I |
| >CA23831| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |