Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA620 | CA23824 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 69 |
| 2 | DDC | 21 |
| 3 | DDI | 65 |
| 4 | AZT | 17 |
| 5 | 3TC+ AZT | 35 |
| 6 | 3TC+ AZT+ SQV | 30 |
| 7 | AZT+ 3TC+ IDV | 66 |
| 8 | AZT+ 3TC | 20 |
| 9 | ADV+ DDI+ EFV | 15 |
| 10 | ADV+ DDI+ EFV | 2 |
| 11 | None | 1 |
| 12 | Unknown | 154 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y188L | V179E | E44D, V60I, V106I, V118I, I135V, G196E, E203K, Q207E, R211K, K223Q, I293V |
| >CA23824| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI YQYVDDLLVGSDLEIEQHRTKIKELREHLWKWGFYTPDNKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | Q58E | L10I, E35D, N37ST, R41RK, I62IV, L63P, I64V, I72V, V77I, I93L |
| >CA23825| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGKWKPKIIGGIGGFVKVREYD QVPVEICGHKAVGTVLIGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |