<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA620 CA23824 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 69
2 DDC 21
3 DDI 65
4 AZT 17
5 3TC+ AZT 35
6 3TC+ AZT+ SQV 30
7 AZT+ 3TC+ IDV 66
8 AZT+ 3TC 20
9 ADV+ DDI+ EFV 15
10 ADV+ DDI+ EFV 2
11 None 1
12 Unknown 154

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N Y188L V179E E44D, V60I, V106I, V118I, I135V, G196E, E203K, Q207E, R211K, K223Q, I293V  
>CA23824| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI
YQYVDDLLVGSDLEIEQHRTKIKELREHLWKWGFYTPDNKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82F, L90M Q58E L10I, E35D, N37ST, R41RK, I62IV, L63P, I64V, I72V, V77I, I93L  
>CA23825| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGKWKPKIIGGIGGFVKVREYD
QVPVEICGHKAVGTVLIGPTPFNIIGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005