Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7115 | CA23769 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+EFV+IDV+LPV | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82VA, L90M | G73S | K20I, M36I, N37S, R41K, I62V, L63P, A71V, I72R, V77VI |
| >CA23769| codons 12-99 TIKIGGQLIEALLDTGADDTVLEEISLPGKWKPKIIGGIGGFVKVRQYDQVPIEICGHKV RSTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215F | G190A, M230L | V108I, F227L | K43N, K49R, V60I, R83K, V90I, V118I, S162D, K166R, T200A, A272P, E297KR, Q334H, G335S, G359S, A371IV, A376AT, V381I, T386TS, A400T, T403M, D460N, Q487E, L491S, S519N, K530KR |
| >CA23768| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISRIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRAKIEELRQHLWRWGFFTPDKKHQKEPPLLWLGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKITTESIIIWGKSPKFKLPIQKETWETWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIHLALEDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |