Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9705 | CA23759 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 52 |
| 2 | NRTI+SQV | 52 |
| 3 | NFV+NRTI | 52 |
| 4 | 3TC+D4T+IDV | 52 |
| 5 | 3TC+D4T+DLV+IDV | 57 |
| 6 | 3TC+ABC+DDI+IDV+RTV | 83 |
| 7 | 3TC+ABC+APV+DDI+RTV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, Q18H, L19T, E35D, L63P, A71V, I72L, I85V, I93L |
| >CA23759| codons 1-98 PQITLWQRPIVTIKIGGHTKEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVLSTVLVGPTPVNVVGRNLMTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N | K20R, K43KE, I142V, S162C, T200A, L228H, Q242QH, A272G, R284RK, T286A, E297KR |
| >CA23758| codons 1-299 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLKGAKALTEVIPLTREA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |