Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9694 | CA23727 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 126 |
| 2 | 3TC+AZT+IDV | 52 |
| 3 | 3TC+D4T+IDV | 48 |
| 4 | 3TC+D4T+RTV+SQV | 190 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, G16E, L63T, I72IV, V77I |
| >CA23727| codons 1-99 PQITLWQRPIVTVKIEGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, V75M, L210W, T215CY | V35E, T39A, S68N, K122E, R211K, I293V, K331KN, Q334N, G335S, A360AT, K366R, T369V, A371V, I375V, A376T, T377L, A400T, E404D, V435A, K451R, D460N, R461K, V466A, S468P, Q480H, H483L, A554S, V559I |
| >CA23726| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAELEKEGKISKIGPENPYNTPV FAIKKKDNSKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQNQGNSQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLVEVVQKVTLESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETRLGKAGYVTNKGRQKAVPLTDTTNQKTELH AILLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKIL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |