Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4461 | CA23714 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 69 |
| 2 | AZT+DDI | 92 |
| 3 | 3TC+AZT+IDV | 130 |
| 4 | D4T+DDI+EFV | 98 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | A62AV | L100LI, K103N | T39A, E44D, A98S, K101X, D123E, I178L, E203K, Q207E, H208Y, R211K, K223KE, L228R, I293V, M357T, R358RK, E370DN, T386I, A400L, K451R, L452LS, D460N, R461K, L491S, E529D, V559VI |
| >CA23714| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIXKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTNAVQKIATESIVIWGKIPKFKLPIQKETWELWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETRSGKAGYVTNKGRQKVVSLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKDKVYLAWVPAHK GIGGNEQVDKLVSAGIRKIL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LI, E35D, K45KR, L63S, I64V, E65D |
| >CA23715| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPRMIGGIGGFIKVRQYD QISVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D6E, E11D, E13ED, S17N, I72V, I113V, S119P, T124N, T125V, I220L, D253E |
| >CA124160| codons 1-288 FLDGIEKAQEDHDKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGPN FTSNVVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKLQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQENSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |