Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5280 | CA23709 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 62 |
| 2 | AZT+ 3TC | 22 |
| 3 | 3TC+AZT+IDV | 145 |
| 4 | D4T+DDI+NFV | 13 |
| 5 | 3TC+D4T+DDI+NFV | 2 |
| 6 | 3TC+D4T+NFV | 15 |
| 7 | NVP+RTV+SQV | 30 |
| 8 | 3TC+APV+AZT+RTV | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, I84V, L90M | L33F, N88D | I15V, R41K, K45R, R57K, L63P, A71V, V82VI, I85V, I93L |
| >CA23709| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADNTVFEEMNLPGKWKPRMIGGIGGFLKVKQYD QIPIEICGHKVIGTVLVGPTPINVVGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR, M184V, T215F | Y188L | K122E, A158S, E169D, G196D, Q207K, V245E |
| >CA23708| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILDPFRKQNPDIVI YQYVDDLLVGSDLEIDQHRTKIEELRKHLLRWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |