Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1166 | CA23703 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | DDC | 21 |
| 3 | D4T | 21 |
| 4 | 3TC+ AZT | 35 |
| 5 | AZT+ D4T | 17 |
| 6 | AZT+ D4T+ IDV | 13 |
| 7 | 3TC+ D4T+ IDV | 47 |
| 8 | 3TC+ D4T+ NFV | 31 |
| 9 | SQV+ RTV+ D4T+ 3TC | 9 |
| 10 | None | 55 |
| 11 | RTV+ IDV+ EFV+ DDI | 19 |
| 12 | IDV+ EFV+ DDI | 63 |
| 13 | LPV+ EFV+ DDI | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15L, L19I, K20R, R41K, L63A, A71V, I93L |
| >CA23703| codons 1-99 PQITLWQRPLVTIKLGGQIREALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIAIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6D, V35M, K122E, I135T, T200I, I202V, V245M, A272P, I293V, E297D |
| >CA23702| codons 1-301 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKVEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTDEAE L |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |