<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5350 CA23690 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 213
2 DDI 91
3 D4T 61
4 AZT+DDC+IDV 60
5 3TC+AZT+IDV 17
6 3TC+D4T+NVP 47
7 ABC+RTV+SQV 113

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82T, I84V, L90M L33F, G73S L10V, I13V, I15V, N37ND, K45R, I62IV, L63P, A71V  
>CA23690| codons 1-99
PQITLWQRPVVTVKVGGQLKEALLDTGADDTVFEEMDLPGRWKPRMIGGIGGFIKVRQYD
QVPIEICGHKVISTVLVGPTPTNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70GR, M184MV, T215F K219Q     V35T, T39A, V60I, T69N, K122E, I135T, T139M, G196E, A272P, E297H  
>CA23689| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSNGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTHEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005