Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3894 | CA23686 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NNRTI+NRTI+PI | 110 |
| 2 | DDI+IDV+RTV | 19 |
| 3 | 3TC+APV+D4T | 35 |
| 4 | 3TC+D4T+LPV | 9 |
| 5 | 3TC+D4T+DLV+SQV | 16 |
| 6 | 3TC+D4T+LPV | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, L33I, Q58QE, G73S | K20R, E35D, M36I, I62V, L63P, I66V, A71V, V82I, Q92K, I93L, C95F |
| >CA23686| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVIEDINLPGRWKPKMIGGIGGFVKVREYD QVPIEVCGHKVISTVLVGPTPINVIGRNLMTKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M, M184V | A62V, V75I, F77L, F116Y | K20R, S68G, T69N, K122E, D123A, I202V, Q207A, R211K, F214L, V245Q, A272P, R284K, I293V |
| >CA23685| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDGNKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEAFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |