Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5058 | CA23682 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDC | 47 |
| 3 | 3TC+D4T | 65 |
| 4 | 3TC+D4T+NFV | 91 |
| 5 | 3TC+D4T+IDV | 30 |
| 6 | 3TC+D4T+RTV+SQV | 21 |
| 7 | 3TC+EFV+IDV | 88 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10I, E35D, L63S, I64V, A71V, I72V, I93L |
| >CA23682| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFIKVRQYD QISVEICGHKVVTTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K101P, K103S | T39A, R83K, K102KR, D123DE, S162F, V179I, E204Q, R211K, H221HY, D250E, A272P, T286A, A288P, E297R |
| >CA23681| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLPRSKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEQLRQHLLKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKPLTEVIPLTREAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |