Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2308 | CA23673 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 17 |
| 2 | 3TC+AZT+IDV | 104 |
| 3 | D4T+DDI+NFV | 57 |
| 4 | ABC+APV+DDI+RTV+SQV | 42 |
| 5 | 3TC+D4T+DDI+EFV | 81 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, M184V, L210LW, T215Y | V75VL | K101E, G190S | K20R, K43KE, K49KR, V60I, V118VI, I135T, T139TR, Q207QH, P294Q |
| >CA23673| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPI FAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRTKIEELRHHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L10F, K43T, G73S, L89V | T12E, I13V, K14KM, G16E, M36L, R41R_R, L63H |
| >CA23674| codons 1-99 PQITLWQRPFVEVMIEGQLKEALLDTGADDTVLEELNLPGRWTPKIIGGIGGFVKVRQYD QIHIEICGHKAISTVLVGPTPANVIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |