Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5349 | CA23672 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 96 |
| 2 | Unknown | 226 |
| 3 | 3TC+D4T+IDV | 61 |
| 4 | 3TC+D4T+NFV | 105 |
| 5 | ABC+D4T+EFV | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | K20I, N37T, K55R, I62V, L63P, I64V, T74S, I93L |
| >CA23672| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEMTLPGRWKPKIIGGIGGFIRVRQYD QVPVEICGHKAIGSVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V | T215I, K219Q | K103N, M230L | K20R, A98S, Q197E, Q207E, R211K, F214L, V245K, D250E, T286A, I293V, D324E, I329L, M357V, T369I, A376C, K390R, T403I, E404D, V435I, E449D, L452S, K512R |
| >CA23671| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGEHRTKIEELREHLLKWGLITPDQKHQKEPPFLWLGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLIEAVQKICTESIVIWGKTPKFRLPIQKETWEAWWIDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRDTKSGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDRSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |