Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5242 | CA23663 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | None | 104 |
| 3 | IDV+ D4T+ 3TC | 104 |
| 4 | None | 20 |
| 5 | DDI+ D4T+ NFV | 138 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | F116Y, N348I | V179D | V35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554S |
| >CA23663| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIDI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVEAETFYVDGAANRETKLGKAGYVTDRGRQKAVSLTDTTNQKAELQ AIHLALQDSGLAVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLINKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90LM | L10FI | I13V, K14KR, K20KM, M36I, I62V, L63P, I64IV, A71V, I93L |
| >CA23664| codons 1-99 PQITLWQRPFVTVRIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD QVPVEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |