Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA798 | CA23644 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 291 |
| 2 | AZT+DDC+SQV | 26 |
| 3 | None | 65 |
| 4 | 3TC+AZT+IDV | 105 |
| 5 | ADV+DDI+EFV | 29 |
| 6 | DDI+EFV | 3 |
| 7 | None | 17 |
| 8 | ABC+ADV+IDV+RTV | 10 |
| 9 | 3TC+ADV+D4T+IDV+RTV | 5 |
| 10 | 3TC+D4T+IDV+RTV | 8 |
| 11 | None | 28 |
| 12 | D4T+DDI+LPV | 42 |
| 13 | None | 13 |
| 14 | 3TC+DDI+RTV+SQV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | G73C | L10I, I15V, G16E, K20M, E35D, M36I, R57K, Q61N, L63C, T74S, I85V, I93L |
| >CA23644| codons 1-99 PQITLWQRPIVTIKVEGQLMEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD NICIEICGHKAICSVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | L100LI, K103KN | V21VI, K43E, K82KR, V118VI, K122E, D177E, T200A, R211K, A272P, T286A, I293V |
| >CA23643| codons 1-304 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNRRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |