Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9670 | CA23630 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 83 |
| 2 | 3TC+AZT | 31 |
| 3 | 3TC+AZT+IDV | 44 |
| 4 | D4T+DDI+IDV | 148 |
| 5 | D4T+DDI+IDV+RTV | 26 |
| 6 | D4T+DDI+IDV | 39 |
| 7 | None | 5 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10FI, K43KT, G73GS | I15IV, Q18QH, L19LI, N37S, I62V, L63P, A71V, V77VI |
| >CA23630| codons 1-99 PQITLWQRPFVTIKVGGHIKEALLDTGADDTVLEEMSLPGRWTPKLIGGIGGFVKVRQYD QVPIEICGHKVISTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | P4Q, E6ED, K43Q, V60I, V118I, I142IV, I178IM, R211T, V245K, A272P, K277R, T286A |
| >CA23629| codons 1-300 PISQIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWTWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |