<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 Unknown NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, G16E, L19I, E35D, M36I, K45R, R57K, L63T, H69K, L89M K14D
>CY243| codons 1-99
PQITLWQRPIVTVDIEGQIKEALLDTGADDTVLEDINLPGRWKPRMIGGIGGFIKVKQYD
QITIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, V60I, K102Q, D121H, K122E, I135T, S162CG, T165TI, K173ST, Q174K, D177E, I178IL, V179VI, T200A, Q207A, R211S, V245EQ, D250E, A272P, T286A, E291D, V292I, I293V, S322A, G335D, M357K, G359S, T369A, A371V, I375V, T377M, K390R, A400L, T403M, E404D, E432D, V435M, D471E, Q480H, H483Y, L491S, S519N, Q524K, K527G, E529D, A534S, A554T, I556V, K558R  
>CY243| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQGSMIKILEPFRTKNPELII
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVKQLAEVVQKVAMESIVIWGKTPKFRLPIQKETWELWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIMGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEKLIGKDKVYLSWVPAHK
GIGGNEQVDKLVSTGVRRVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, V31I, V32I, D41N, I60V, I72V, T112V, I113V, T124A, T125A, G134N, K136Q, D167E, F181Y, V201I, I208L, T218I, L234I S283G
>CY243| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPIIAKEIVASCNKCQLKGEAMHGQVDCSPGV
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSAAVKAACWWANIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
YIHNFKRKGGIGGYSAGERIIDIIATDLQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Kousiappa, I Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance. ARHR, 2011