Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CY222 | CY222 | Cyprus | 2008 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| Q95K, G140E | V32I, E35K, K42R, G70E, L101I, T112I, T124G, T125A, K136Q, M154I, E157K, R166K, V201I, L234I, D256E, V260I | E152K, S283G |
| >CY222| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVIAKKIVASCDRCQLKGEAMHGQVDCSPGI WQLDCTHLEEKIILVAVHVASGYIEAEVIPAETGKETAYFILKLAGRWPVKIIHTDNGSN FTSGAVKAACWWAGIQQEFEIPYNPQSQGVVKSINKKLKKIIGQVKDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSEIKVIPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, T12V, I13V, I15V, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72T, L89M |
| >CY222| codons 1-99 PQITLWQRPVVVVKVGGQLKEALLDTGADDTVLEDINLPGKWRPKMIGGIGGFIKVKQYD QITIDICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, D123E, I135L, K173V, Q174K, T200I, Q207A, R211K, V245Q, E248D, A272P, V276I, K277R, T286A, E291D, V292I, I293V, E297A, I326V, F346C, R356K, G359S, A376V, T377Q, T386I, E396K, W402*, T403I, E404D, K431T, V435T, A446S, L452I, D471E, T477A, L491S, Q524R, K527Q, A534S, G543R, A554N, V559I | E302K |
| >CY222| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRVKNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKIRQLCKLLRGAKALTDIVPLTAEAE LKLAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPCKNLKTGKYAKMRSA HTNDVKQLTEAVQKIVQESIVIWGKIPKFKLPIQKKTWEAW*IDYWQATWIPEWEFVNTP PLVKLWYQLETEPITGAETFYVDGASNRETKIGKAGYVTDRGRQKVVSLTETTNQKAELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIERLIQKEKVYLSWVPAHK GIRGNEQVDKLVSNGIRKIL |
References
| Author | Title | Citation |
| Kousiappa, I | Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance. | ARHR, 2011 |