<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 Unknown NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, L101I, T112V, I113V, T124A, T125A, G134D, E157Q, I191M, V201I, T206S, L234I S283G, D286E, D288N
>CY217| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVVHTDNGSN
FTSAAVKAACWWADIKQEFGIPYNPQSQGVVESMNKQLKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGMGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQEEN

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, K20I, M36I, N37D, R41K, L63P, H69K, L89M  
>CY217| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, V35T, E36D, T39V, K122E, D123G, I135V, Q145R, S162A, K173A, Q174K, D177G, T200I, Q207A, R211S, V245L, T286A, E291D, I293V, S322T, I326V, G335D, R356K, M357R, G359T, T369A, A371V, I375V, T377I, K390R, K395R, A400T, T403M, T409S, E432D, V435A, T450N, V458I, D471E, Q480H, L491S, K512R, S519N, Q520L, Q524E, K527G, E529D, A534S, A554N R143E, Y144C
>CY217| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTDICVEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSVNNETPGIECRYNVLPQGWKGSPAIFQASMTKILEPFRAKNPGIVI
YQYMDDLYVGSDLEIGQHRIKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPILLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLAEVVQKVAIESIVIWGKTPKFRLPIQRETWETWWMEYWQASWIPEWEFVNTP
PLVKLWYQLEKDPIAGAETFYVDGAANRENKLGKAGYITDRGRQKVVSLTETTNQKTELH
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNLIIEELIGKDKVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Kousiappa, I Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance. ARHR, 2011