<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 Unknown NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, M36I, N37D, R57RK, L63H, I64M, H69K, I72V, L89M, I93L  
>CY205| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVKQYD
QIHMEICGKKAVGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, E53ED, K104R, K122E, S162Y, K173A, D177E, I178M, I195L, G196E, T200A, E204K, Q207E, P243T, V245Q, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, G333E, Q334H, G335D, R356K, M357R, G359T, T377R, T386I, K390R, E399D, A400S, E404D, L422I, V435A, S468T, D471E, H483Q, L491S, E492K, S519N, K527N, E529D, A534S, V548A, A554S  
>CY205| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPDNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAQNPEMVI
YQYMDDLYVGSDLELEQHRAKIEKLREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQTIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIARESIVIWGKIPKFRLPIQKETWDSWWTDYWQATWIPEWEFVNTP
PIVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVTLTETTNQKTELQ
AIQLALQDSGSKVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKDKVYLSWVPAHK
GIGGNEQADKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, D278A P29A, S283G
>CY205| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLAPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGTN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Kousiappa, I Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance. ARHR, 2011