<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 Unknown NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, T12K, I15V, L19I, E35D, M36I, R41K, K43R, R57K, L63V, E65D  
>CY191| codons 1-99
PQITLWQRPIVKIKVGGQIKEALLDTGADDTVLEDINLPGKWRPKMIGGIGGFIKVKQYD
QIVIDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20KR, V35T, T39L, K49R, K101KQ, D123E, S162C, E169D, K173A, I178L, E204Q, Q207A, P243Q, V245Q, E248D, S251I, A272S, T286A, A288T, E291D, V292I, I293V, P294T, E297A, V317A, A327G, E328K, I329T, Q330P, I341F, R356K, M357R, G359S, T369A, A371V, T377M, K390R, A400T, T403M, E432D, V458I, R461K, D471E, Q480H, H483W, L491P, K512R, L517I, S519N, Q524K, K527E, A534S, A554S  
>CY191| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICLEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEQLRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQQIQLPDKDIWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKTLTDIVTLTAEAE
LELAENREILKEPVHGAYYDPSKDLIGKTPKQGQGQWTYQFYQEPFKNLKTGKYAKRRSA
HTNDVKQLAEVVQKIAMESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYITDKGRQKVVSLTETTNQKTELH
AIWLALQDSGPEVNIVTDSQYALGIIQAQPDRSESEIVNQIIEKLIEKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, K14R, V31I, A80P, T124S, T125A, I135V, K136Q, G189R, V201I, I220L, Y227F, L234V, S255N R284G, D288N
>CY191| codons 1-288
FLDGIDKAQEDHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVPSGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSSAVKAACWWAGVQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKRGIGGYSAGERIIDIIATDIQTKELQKQITKLQNFRVYFRDSRDPVWKGPAK
LLWKGEGAVVIQDNNDIKVVPRRKAKIIRDYGKQMAGDDCVASGQDEN

References
Author Title Citation
Kousiappa, I Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance. ARHR, 2011