Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6595 | CA23578 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 104 |
| 2 | D4T+DDI+NFV+NVP | 22 |
| 3 | D4T+DDI+EFV+NFV | 17 |
| 4 | 3TC+D4T+NFV | 78 |
| 5 | ABC+APV+D4T+RTV | 68 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A | L24I, L33F | L10I, K14KR, I15IV, Q18QH, N37D, I62V, L63P, A71V, T74A, T91TA |
| >CA23578| codons 1-99 PQITLWQRPIVTIRVGGHLKEALIDTGADDTVFEEMDLPGRWKPKLIGGIGGFLKVRQYD QVPIEICGHKVIGAVLVGPTPANIIGRNLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, L210LW, T215Y | K122E, I135L, S162C, T200A, E203ED, L228LH, A272P, I293V, E297Q |
| >CA23577| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTQEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |