<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5410 CA23556 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 13
2 3TC+DDC+IDV 26
3 3TC+DDC+SQV 21
4 3TC+D4T+NFV 223

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N N88D L10I, I13IV, K43R, Q61E, L63P, T74S, V77I, L89LM, I93L  
>CA23556| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADNTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD
EIPIEICGHKAIGSVLIGPTPVNIIGRDMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y A62AV     V35L, T39A, K122E, E138EG, T139K, I142IL, A158AS, E169D, K173E, I178L, G196E, T200A, Q207E, A272P, K277R, I293V, E297EK I159IL, L283LF
>CA23555| codons 1-301
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNGKPGLRYQYNVLPQGWKGSPSLFQSSMTKILDPFREQNPDLVI
YQYVDDLYVGSDLEIEQHRAKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLFRGTKALTEVVPLTKEAE
L

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005