Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4767 | CA23524 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | AZT+SQV | 48 |
| 3 | 3TC+AZT+IDV | 78 |
| 4 | 3TC+AZT+NFV | 67 |
| 5 | 3TC+AZT+EFV | 36 |
| 6 | ABC+D4T+LPV | 65 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37E, L63A, I72V, V77I, I93L |
| >CA23524| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMELPGRWKPKMIGGIGGFIKVRQYD QIAIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103KN | K20KR, V35T, V60I, K102Q, K122P, K166R, D177E, I178M, T200A, R211KT, V245VM, E248ED, D250E, A272P, K277R, T286A, V292I |
| >CA23523| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIIPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |