Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4345 | CA23507 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | D4T+IDV | 48 |
| 3 | 3TC+NFV | 65 |
| 4 | RTV+SQV | 39 |
| 5 | D4T+NVP+SQV | 70 |
| 6 | AZT+DDI+LPV | 55 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67DG, K219N | Y181C, G190GA | K20R, E44D, S68G, K101KQ, V118I, K122E, D123E, A272P, E291D, V292I |
| >CA23507| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIIPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48Q, I54T, V82F, L90M | L33F, K43T | L10I, K20R, E35D, M36I, N37D, R41K, Q61QE, I62V, L63T, I72V, V77I, L89I, I93L |
| >CA23508| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDIDLPGKWTPKIIQGIGGFTKVRQYD EVTIEICGHKAVGTVLIGPTPFNIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |