Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| UK1446 | UK1446 | U.K. | 2001 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NVP+ 3TC+ AZT | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K20R, M36I, R41K, I62V, I64V, I72V |
| >UK1446| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QVLVEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | G190A | V8I, V35T, K49R, V60I, K122E, I135L, I142V, D177E, I178M, T200I, E203K, Q207E, R211K |
| >UK1446| codons 1-234 PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVASDLEIGQHRIKIKELREHLLKWGFTTPDKKHQKEPPFLWMGYEL |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |