<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1436 UK1436 U.K. 2001 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 DDC+ NVP+ AZT NA
2 SQV+ RTV+ 3TC+ D4T NA
3 D4T+ 3TC+ NFV 123

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   Y181V   E6D, V21I, V35T, V60I, R83K, K122E, D123S, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, H221Y  
>UK1436| codons 1-234
PISPIDTVPVKLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPELII
VQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKYQKEPPFLWMGYEL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  N83D I13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91A  
>UK1436| codons 1-99
PQITLWQRPLVTVRIGGQLREVLLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVDIIGRNILAQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005