<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1154 UK1154 U.K. 2000 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ AZT NA
2 NFV+ 3TC+ D4T NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       V8I, V35T, T39E, K122E, I135T, A158S, K173A, Q174R, D177E, I178M, T200A, Q207E, R211Q  
>UK1154| codons 1-226
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRARNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLQWGFYTPDKKHQKEPP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93L  
>UK1154| codons 1-99
PQITLWQRPLVSVKVGGQITEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE
QIPVEICGKKAIGTVLVGPTPINIIGRNMMTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005