Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| UK356b | UK356b | U.K. | 2000 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+ 3TC+ AZT | 8 |
| 2 | 3TC+ AZT | 39 |
| 3 | D4T+ DDI+ NVP | 39 |
| 4 | RTV+ DDI+ D4T | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215F | Y181C, G190A | V21I, V35T, E36A, T39E, K122E, D123N, S162C, K173A, D177E, V179T, T200A, Q207D, R211K |
| >UK356b| codons 1-229 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAQNPEITI CQYMDDLYVASDLEIGQHRAKIEELRDHLLKWGFFTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L |
| >UK356b| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEELNLPGKWKPKMIGGIGGFIKVRQYE QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |