<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK356b UK356b U.K. 2000 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 NFV+ 3TC+ AZT 8
2 3TC+ AZT 39
3 D4T+ DDI+ NVP 39
4 RTV+ DDI+ D4T 36

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L  
>UK356b| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEELNLPGKWKPKMIGGIGGFIKVRQYE
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T215F   Y181C, G190A   V21I, V35T, E36A, T39E, K122E, D123N, S162C, K173A, D177E, V179T, T200A, Q207D, R211K  
>UK356b| codons 1-229
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAQNPEITI
CQYMDDLYVASDLEIGQHRAKIEELRDHLLKWGFFTPDKKHQKEPPFLW

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005