Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| BE59 | BE59 | Belgium | 2000 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | SQV+ AZT+ DDC | 51 |
| 3 | D4T+ DDI+ IDV | 13 |
| 4 | IDV+ AZT+ 3TC+ DDI+ D4T | 1 |
| 5 | AZT+ 3TC+ IDV | 30 |
| 6 | AZT+ SQV+ RTV+ 3TC | 21 |
| 7 | 3TC+ AZT | 24 |
| 8 | ABC+ NFV+ NVP | 5 |
| 9 | NVP+ NFV+ D4T | 20 |
| 10 | 3TC+ NFV+ SQV | 76 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A | L33F, K43KT | L10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93L |
| >BE59| codons 1-99 PQITLWQRPIVTVKVGGQIKEALLDTGADDTVFEELEMPGRWTPKMIVGIGGFAKVRQYD QVVIEICGKKAVGSVLVGPTPANIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215HY | K219N | G190GA | F227FL | P4PS, K20R, V35T, T39E, E44D, K122E, T139TA, K173T, I178IM, T200E, E203K, Q207E, H208Y, R211K, K223E, L228LR, V245H, D250E, A272P, L283I, T286V, E291D, V292I, I293V, D324E |
| >BE59| codons 1-325 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPDMVI YQYVDDLYVASDLEIGQHREKIKELREYLWKWGFYTPDNKHQEEPPLRWMGYELHPDKWT VQPIHLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGVKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKEL |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |
| Snoeck, J | Rising prevalence of HIV-1 non-B subtypes in Belgium: 1983-2001. | JAIDS, 2004 |