Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1161 | CA23194 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+ DDC | 52 |
| 3 | AZT+ DDI | 52 |
| 4 | D4T+ DDI | 52 |
| 5 | AZT+ DDC | 52 |
| 6 | 3TC+ AZT+ DDC | 43 |
| 7 | 3TC+ AZT+ D4T+ SQV | 17 |
| 8 | 3TC+ AZT+ D4T+ RTV+ SQV | 26 |
| 9 | 3TC+ AZT+ D4T+ DLV+ IDV | 25 |
| 10 | 3TC+ D4T+ NFV | 26 |
| 11 | D4T+ DDI | 30 |
| 12 | D4T+ DDI+ EFV+ ADV | 26 |
| 13 | ABC+ RTV+ SQV | 8 |
| 14 | APV+ ABC | 43 |
| 15 | LPV+ ABC+ D4T+ DDI | 109 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, K43T, F53L, T74P | E34Q, M36L, I62V, L63A, A71V, I93L |
| >CA23194| codons 15-99 IGGQLKEALLDTGADDTIFQELNLPGRWTPKIVGGIGGLLKVRQYDQVAIEICGHKVIGP VLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67~, K70R, L74I, T215F | T69G, K219Q | L100LI, K103N | E6D, K20R, T39N, K43E, K101X, K102R, D123E, K166R, D177E, V179I, G196K, T200I, Q207E, V245K, A272P, K277R, I293V | P157A |
| >CA23195| codons 1-301 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV FAIKKK~SGRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIXRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSAAIFQSSMTRILEPFRKQNPEIII YQYMDDLYVGSDLEIKQHRIKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |