Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5617 | CA23189 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 70 |
| 2 | 3TC+AZT+IDV | 105 |
| 3 | 3TC+D4T+IDV | 118 |
| 4 | APV+D4T+EFV | 38 |
| 5 | ABC+EFV+LPV | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, L90M | Q58QE | L10I, I13V, K20I, E35D, M36I, I62V, L63P, I64V, A71V, I72V, I93L |
| >CA23189| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVREYD QVPVEICGHKVVGTVVVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K101E, Y181C, G190S | E6K, K43N, V106VI, V118I, K122E, I135V, V179I, V189VI, T200A, E203D, R211K, L228H |
| >CA23188| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYMDDLYISSDLEIGQHRAKIDELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |