<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4323 CA23185 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 87
2 DDI 148
3 AZT+DDC+DLV 83
4 RTV+SQV 35
5 D4T+EFV+RTV+SQV 31
6 3TC+ABC+APV+D4T 114

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M L10F, L33F I13V, K20T, E35D, M36I, R41K, D60E, I62V, L63P, A71V, P79H  
>CA23185| codons 1-99
PQITLWQRPFVTVKIGGQLTEALLDTGADDTVFEDINLPGKWKPKMIGGIGGFIKVRQYE
QVPIEICGHKVIGTVLVGHTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y K219N K103N L234I K43E, E44EA, K64R, V118I, D123E, T200A, E203K, Q207E, D218DE, F227Y, L228H, T286A, I293V  
>CA23184| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIRKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIKELREHLWRWGFYTPENKHQKEPPYHWMGYEIHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005