<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2076 CA23182 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T 31
2 D4T+IDV 48
3 D4T+NFV+NVP 23
4 3TC+AZT+NFV+NVP 10
5 3TC+ABC+AZT+EFV 30
6 D4T+DDI+RTV+SQV 91

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219KN Y188L   K43E, E44A, K102M, V118I, K122E, I142IV, R211N, A272P, E291D, I293V  
>CA23182| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLLVGSDLEIGQHRTKIEELRQHLWNWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54IL, I84V, L90M   I13IL, K14E, L19LV, K20MT, E35G, M36I, R57K, Q61E, I62V, L63P, I64IV, E65N, K70KE, A71V, P79PA, Q92K, I93L  
>CA23183| codons 12-99
TLEIGGQVMEALLDTGADDTVLEGINLPGRWKPKLIGGIGGFLKVKQYDEVPVNICGHEV
IGTVLVGATPVNVIGRNLMTKLGCTLNF

References
Author Title Citation
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005