Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2076 | CA23182 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 31 |
| 2 | D4T+IDV | 48 |
| 3 | D4T+NFV+NVP | 23 |
| 4 | 3TC+AZT+NFV+NVP | 10 |
| 5 | 3TC+ABC+AZT+EFV | 30 |
| 6 | D4T+DDI+RTV+SQV | 91 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KN | Y188L | K43E, E44A, K102M, V118I, K122E, I142IV, R211N, A272P, E291D, I293V |
| >CA23182| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLWNWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IL, I84V, L90M | I13IL, K14E, L19LV, K20MT, E35G, M36I, R57K, Q61E, I62V, L63P, I64IV, E65N, K70KE, A71V, P79PA, Q92K, I93L |
| >CA23183| codons 12-99 TLEIGGQVMEALLDTGADDTVLEGINLPGRWKPKLIGGIGGFLKVKQYDEVPVNICGHEV IGTVLVGATPVNVIGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |